Tom, that's what's amphetamines are used for. Amphetamines disgorges dopamine from the synaptic vesicles that are recycling the neurotransmitter in addition to pumping even more dopamine into the synapse, while cocaine blocks the reuptake gates in the axion terminal, forcing more dopamine and other neurochemcials to be present and used. This is why "speedballs" are so potent.

_x, I think AME-359 has to be consumed by humans. There were NIDA studies awhile back that some folks had an immunity to cocaine, as the drug would have to cross the blood-brain barrier and get antibodies attached to the compound. They even experimented on rats, give them an immunity to cocaine by introducing a "vaccine" drug. Perhaps this is the end result, a counteragent based off that research. However, it is mentioned that it is an enzyme, so it could be done before ingestion.