PyObjC is definitely worth playing with. It takes a touch of getting used to, but if you are coding GUIs aimed at Mac OS X users, this is the way to go. Not to mentioned better integration with OS X in general.

As of right now, I have not found a way to compile mod_python for the standard install of Apache, but Python runs wonderfully as cgi on OS X and is now my prefered web app coding environment.

The OS X built in XML parsers rock as well. Very fast and not resource intensive.

I've more or less stopped using Java and am now coding almost entirely in Python using OS X as my development platform. It rocks.

Take care,
Dave Giffin
http://www.davtri.com